Matrix Metalloproteinases: Drug Targets for Myocardial Infarction
نویسندگان
چکیده
منابع مشابه
Clinical significance of matrix metalloproteinases activity in acute myocardial infarction.
Matrix metalloproteinases (MMP) degrade myocardial fibrillar collagen in acute myocardial infarction (MI) patients. Their activity is tightly controlled in normal myocardium by a family of closely related tissue inhibitors known as TIMP. An imbalance in their activity might contribute to post-MI remodeling. Plasma levels of MMP-1, TIMP-1 and MMP-1/TIMP-1 complex were measured, using relevant EL...
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Matrix metalloproteinases-12 (MMP12) can lead to degradation of elastin resulting in plaque destabilization and rupture. MMP12 also facilitates platelet aggregation, adhesion, and granule secretion. However, evidence in the literature related to the function of MMP12 in ST-segment elevation myocardial infarction (STEMI) is little. This study investigated the expression of MMP12 in human coronar...
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Matrix Metalloproteinases (MMPs), a class of Zn containing enzymes are involved in the erosion of the fibrous cap and rupture of the plaque which leads to Acute Myocardial Infarction (AMI). Though the exact mechanism of the involvement of MMPs in AMI is not clear, evidence suggest that they play a major role in different phases of AMI. Our aim was to evaluate the role of MMP2 and MMP9 in AMI pa...
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The myocardial extracellular matrix plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in post-myocardial infarction repair processes. We analysed some genetic and proteomic aspects that could play an important role in the development of myocardial infarction. Matrix metalloproteinases are enzymes that contribute strongly to the...
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The post-myocardial infarction wound repair process involves temporarily overlapping phases that include inflammation, formation of granulation tissue, scar formation, and overall left ventricle (LV) remodelling. The myocardial extracellular matrix (ECM) plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in wound repair post-myo...
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ژورنال
عنوان ژورنال: Current Drug Targets
سال: 2013
ISSN: 1389-4501
DOI: 10.2174/138945013804999007